▪ Abstract Major histocompatibility complex (MHC) class I molecules display on the cell
surface 8-to 10-residue peptides derived from the spectrum of proteins expressed in the …

▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …

Precursors to major histocompatibility complex (MHC) class I–presented peptides with extra
NH2-terminal residues can be efficiently trimmed to mature epitopes in the endoplasmic …

The proteasome inhibitor PS-341 inhibits IκB degradation, prevents NF-κB activation, and
induces apoptosis in several types of cancer cells, including chemoresistant multiple …

LMP2, LMP7, and MECL are interferon γ–inducible catalytic subunits of vertebrate 20S
proteasomes, which can replace constitutive catalytic subunits (delta, X, and Z, respectively) …

Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a
nonspecific and abundant barrel-shaped complex called the 20S proteasome. Substrates …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

▪ Abstract Proteasomes are large multisubunit proteases that are found in the cytosol, both
free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their …

Investigators have long recognized the potential importance of protein degradation as a
mechanism for regulating levels of cellular proteins (1–3). Nevertheless, only recent studies …