The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history

PS Sorensen, F Sellebjerg, HP Hartung, X Montalban… - Brain, 2020 - academic.oup.com
In the past decade, changes have occurred in the spectrum of multiple sclerosis courses.
The natural history of multiple sclerosis appears milder from the first sign of demyelinating …

Current knowledge on multiple sclerosis pathophysiology, disability progression assessment and treatment options, and the role of autologous hematopoietic stem …

G Gakis, I Angelopoulos, I Panagoulias… - Autoimmunity Reviews, 2023 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
affects nearly 2.8 million people each year. MS distinguishes three main types: relapsing …

E-health and multiple sclerosis

PM Matthews, VJ Block, L Leocani - Current opinion in neurology, 2020 - journals.lww.com
E-health and multiple sclerosis : Current Opinion in Neurology E-health and multiple sclerosis :
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new issue …

The MSBase registry: informing clinical practice

T Kalincik, H Butzkueven - Multiple Sclerosis Journal, 2019 - journals.sagepub.com
Over the last decade, clinical registries have significantly contributed to the pool of evidence
that supports management decisions in patients with multiple sclerosis. Being the largest …

Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry

H Butzkueven, T Spelman, D Horakova… - European journal of …, 2022 - Wiley Online Library
Abstract Background and purpose Reaching Expanded Disability Status Scale (EDSS)≥ 7.0
represents the requirement for a wheelchair. Here we (i) assess the effect of ocrelizumab on …

Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

T Chu, LBE Shields, W Zeng, YP Zhang… - Neural Regeneration …, 2021 - journals.lww.com
Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin
sheath in the central nervous system. It is characterized by blood-brain barrier dysfunction …

Disease activity in primary progressive multiple sclerosis: a systematic review and meta-analysis

KM Blok, J van Rosmalen, N Tebayna… - Frontiers in …, 2023 - frontiersin.org
Background Disease activity in multiple sclerosis (MS) is defined as presence of relapses,
gadolinium enhancing lesions and/or new or enlarging lesions on MRI. It is associated with …

[HTML][HTML] Ocrelizumab treatment in patients with primary progressive multiple sclerosis: short-term safety results from a compassionate use programme in Germany

S Rauer, MM Hoshi, R Pul, M Wahl, M Schwab… - Clinical neurology and …, 2020 - Elsevier
Abstract Objectives In January 2018, the European Union (EU) approved ocrelizumab in
relapsing multiple sclerosis (RMS) and as the first disease-modifying therapy (DMT) for …

Recurrent disability progression endpoints in multiple sclerosis clinical trials

A Bühler, M Wolbers, F Model, Q Wang… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: The current standard endpoint to assess disability accumulation in multiple
sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which …

Effectiveness and safety of dimethyl fumarate in progressive multiple sclerosis

VF Moreira Ferreira, Y Liu, BC Healy… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background There is limited data analyzing the safety and effectiveness of dimethyl
fumarate (DMF) in the progressive multiple sclerosis (PMS) population. Objective To analyze …