Research into dementia prevention is of paramount importance if the dementia epidemic is
to be halted. Observational studies have identified several potentially modifiable risk factors …

Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Abstract Introduction The 2‐year Finnish Geriatric Intervention Study to Prevent Cognitive
Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Background Several risk factors contribute to dementia, but the role of obesity remains
unclear. This study investigated whether increased body weight or central obesity were …

Objective To forecast dementia prevalence with a dynamic modelling approach that
integrates calendar trends in dementia incidence with those for mortality and cardiovascular …

The demographic structure of Latin American countries (LAC) is fast approaching that of
developing countries, and the predicted prevalence of dementia in the former already …

Background Informal caregivers of persons living with dementia have an increased risk of
adverse mental health effects. It is therefore important to systematically summarize …

Introduction We investigate dementia risk in older adults with different disease patterns and
explore the role of inflammation and apolipoprotein E (APOE) genotype. Methods A total of …

Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol
II) transcription. To study the in vivo dynamics of endogenous Pol II during these steps, we …