Viruses have some characteristics in common with cell-based life. They can evolve and
adapt to environmental conditions. Directed evolution can be used by researchers to …

At the end of my doctoral studies, in 1988, I published a review article on the major steps of
transcription and translation during the mammalian reovirus multiplication cycle, a topic that …

Viruses are extensively studied as pathogens and exploited as molecular tools and
therapeutic agents. Existing methods to purify viruses such as gradient ultracentrifugation or …

Reoviruses, like many eukaryotic viruses, contain an inverted 7-methylguanosine (m7G) cap
linked to the 5′ nucleotide of mRNA. The traditional functions of capping are to promote …

Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was
first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV …

Viruses that specifically replicate in tumor over normal cells offer promising cancer
therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti …

As with most viruses, mammalian reovirus can be recognized and attacked by the host-cell
interferon response network. Similarly, many viruses have developed resistance …

Following attachment to host receptors via σ1, reovirus particles are endocytosed and
disassembled to generate infectious subvirion particles (ISVPs). ISVPs undergo …

It has been previously shown that amino acid polymorphisms in reovirus proteins μ2 and λ1
are associated with differing levels of interferon induction. In the present study, viruses …

In the course of previous works, it was observed that the virus laboratory stock (T3D S)
differs in sequence from the virus encoded by the ten plasmids currently in use in many …