Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy

MA Peltoniemi, NM Hagelberg, KT Olkkola… - Clinical …, 2016 - Springer
Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-
methyl-d-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the …

Remifentanil tolerance and hyperalgesia: short‐term gain, long‐term pain?

EHY Yu, DHD Tran, SW Lam, MG Irwin - Anaesthesia, 2016 - Wiley Online Library
The unique pharmacology of remifentanil makes it a popular intra‐operative analgesic.
Short‐acting opioids like remifentanil have been associated with acute opioid tolerance …

[HTML][HTML] Intraoperative use of remifentanil and opioid induced hyperalgesia/acute opioid tolerance: systematic review

SH Kim, N Stoicea, S Soghomonyan… - Frontiers in …, 2014 - frontiersin.org
Introduction: The use of opioids has been increasing in operating room and intensive care
unit to provide perioperative analgesia as well as stable hemodynamics. However, many …

Intraoperative methadone in surgical patients: a review of clinical investigations

GS Murphy, JW Szokol - Anesthesiology, 2019 - pubs.asahq.org
Intraoperative Methadone in Surgical Patients | Anesthesiology | American Society of
Anesthesiologists Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt Text …

Thalamocortical circuits drive remifentanil-induced postoperative hyperalgesia

Y Jin, Y Mao, D Chen, Y Tai, R Hu… - The Journal of …, 2022 - Am Soc Clin Investig
Remifentanil-induced hyperalgesia (RIH) is a severe but common postoperative clinical
problem with elusive underlying neural mechanisms. Here, we discovered that …

Opioid-based anesthesia and analgesia for adult cardiac surgery: history and narrative review of the literature

LE Kwanten, B O'Brien, S Anwar - Journal of Cardiothoracic and Vascular …, 2019 - Elsevier
Opioids have played in a key role in cardiac anesthesia and analgesia since the early years
of cardiac surgery. Today, opioids continue to be the primary mode for analgesia in cardiac …

Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice

GR Lauder - Pediatric anesthesia, 2015 - Wiley Online Library
Inhalational anesthesia has dominated the practice of pediatric anesthesia. However, as the
introduction of agents such as propofol, short‐acting opioids, midazolam, and …

Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia

M Comelon, J Raeder, A Stubhaug… - BJA: British Journal …, 2016 - academic.oup.com
Background The aim of this study was to examine if gradual withdrawal of remifentanil
infusion prevented opioid-induced hyperalgesia (OIH) as opposed to abrupt withdrawal. OIH …

Randomized controlled trial on the influence of intraoperative remifentanil versus fentanyl on acute and chronic pain after cardiac surgery

S de Hoogd, SJGM Ahlers, EPA van Dongen… - Pain …, 2018 - Wiley Online Library
Background Remifentanil has been associated with increased acute and potentially chronic
postoperative pain. The objective of this prospective randomized controlled trial was to …

Effective dose of intravenous dexmedetomidine to prolong the analgesic duration of interscalene brachial plexus block: a single-center, prospective, double-blind …

RA Kang, JS Jeong, JC Yoo, JH Lee… - Regional Anesthesia & …, 2018 - rapm.bmj.com
Background and Objectives Intravenous (IV) dexmedetomidine (DEX) is reported to prolong
the analgesic duration after single-shot interscalene brachial plexus block (ISBPB) …