Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Brain pericytes are perivascular cells that regulate capillary function, and this localization
puts them in a pivotal position for the regulation of central nervous system (CNS) …

Brain pericytes and vascular smooth muscle cells (vSMCs) are a critical component of the
neurovascular unit and are important in regulating cerebral blood flow and blood-brain …

Background Transforming growth factor beta 1 (TGFβ 1) is strongly induced following brain
injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ 1 …

Background Microglia play critical roles in the brain during homeostasis and pathological
conditions. Understanding the molecular events underpinning microglial functions and …

Pericytes (PC) are mural cells that surround endothelial cells in small blood vessels. PC
have traditionally been credited with structural functions, being essential for vessel …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Parkinson's disease (PD) is characterized by the presence of inclusions known as Lewy
bodies, which mainly consist of α-synuclein (α-syn) aggregates. There is growing evidence …

Amyotrophic lateral sclerosis (ALS) is an incurable and rapidly progressive neurological
disorder. Biomarkers are critical to understanding disease causation, monitoring disease …

Background Pericytes and endothelial cells are critical cellular components of the blood-
brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of …