Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …

OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone
crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the …

Aims/hypothesis Zinc is highly concentrated in pancreatic beta cells, is critical for normal
insulin storage and may regulate glucagon secretion from alpha cells. Zinc transport family …

Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc
concentration is in insulin secretory granules, from which it is cosecreted with the hormone …

Homeostatic control maintains essential transition metal ions at characteristic cellular
concentrations to support their physiological functions and to avoid adverse effects. Zinc is …

Thyroid hormones play an important role in body homeostasis by facilitating metabolism of
lipids and glucose, regulating metabolic adaptations, responding to changes in energy …