[HTML][HTML] Quantitative NMR-based biomedical metabolomics: Current status and applications

AA Crook, R Powers - Molecules, 2020 - mdpi.com
Nuclear Magnetic Resonance (NMR) spectroscopy is a quantitative analytical tool
commonly utilized for metabolomics analysis. Quantitative NMR (qNMR) is a field of NMR …

Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

K Sonkar, V Ayyappan, CM Tressler… - NMR in …, 2019 - Wiley Online Library
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

O Beckonert, M Coen, HC Keun, Y Wang… - Nature protocols, 2010 - nature.com
Metabolic profiling, metabolomic and metabonomic studies require robust study protocols for
any large-scale comparisons and evaluations. Detailed methods for solution-state NMR …

Metabolite profiling of fecal water extracts from human colorectal cancer

D Monleón, JM Morales, A Barrasa… - NMR in Biomedicine …, 2009 - Wiley Online Library
Colorectal cancer is the second leading cause of cancer death in developed countries.
There is a need for better preventive strategies to improve the outcome of this disease. The …

NMR techniques in biomedical and pharmaceutical analysis

M Malet-Martino, U Holzgrabe - Journal of pharmaceutical and biomedical …, 2011 - Elsevier
This article focuses on the description of some of the NMR techniques used in the field of
biomedical and pharmaceutical research. Indeed, the NMR method has special …

Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy

B Sitter, TF Bathen, TE Singstad… - NMR in Biomedicine …, 2010 - Wiley Online Library
Absolute quantitative measures of breast cancer tissue metabolites can increase our
understanding of biological processes. Electronic REference To access In vivo …

Advances in NMR-based biofluid analysis and metabolite profiling

S Zhang, GAN Gowda, T Ye, D Raftery - Analyst, 2010 - pubs.rsc.org
Significant improvements in NMR technology and methods have propelled NMR studies to
play an important role in a rapidly expanding number of applications involving the profiling …

Metabolomics biomarkers for breast cancer

UL Günther - Pathobiology, 2015 - karger.com
Metabolomics represents a more recent addition to the range of omics tools, which are
increasingly used in clinical applications. By measuring the composition of small molecules …

HR MAS MR spectroscopy in metabolic characterization of cancer

S Moestue, B Sitter, T Frost Bathen… - Current topics in …, 2011 - ingentaconnect.com
One of the central hallmarks of cancer is the rapid and infinite cellular proliferation. In order
to cope with increased requirement for building blocks and energy, cancer cells develop …

A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors

C Choi, S Ganji, K Hulsey, A Madan… - NMR in …, 2013 - Wiley Online Library
2‐Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate
dehydrogenase (IDH) 1 and 2. The 1H resonances of the J‐coupled spins of 2HG are …