Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases
Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …
Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions
Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …
temperature, and metabolism—all the functions needed for an individual's health and well …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
[HTML][HTML] Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease
Sarcopenia and myopathies cause progressive muscle weakness and degeneration, which
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …
Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle
Skeletal muscle has the remarkable ability to regenerate. However, with age and disease
muscle strength and function decline. Myofiber size, which is affected by injury and disease …
muscle strength and function decline. Myofiber size, which is affected by injury and disease …
Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease
The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …
[HTML][HTML] TGF-β–driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model
Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor
myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic …
myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic …
A discrete 'early-responder'stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Following acute injury, stromal cells promote tissue regeneration by a diversity of
mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal …
mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal …
Interactions between muscle and bone—where physics meets biology
M Herrmann, K Engelke, R Ebert, S Müller-Deubert… - Biomolecules, 2020 - mdpi.com
Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …
Physical forces are generated through gravity, locomotion, exercise, and external devices …