Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

ISPAD Clinical Practice Consensus Guidelines 2022: Insulin treatment in children and
adolescents with diabetes Page 1 ISPAD GUIDELINES ISPAD Clinical Practice Consensus …

Insulin treatment that mimics normal physiological patterns as closely as possible remains
the cardinal principle of treatment for type 1 diabetes. Since the last guidelines were …

Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical
manifestations of DM are not indicative of the cause of the disease, but might be indicative of …

Insulin therapy (IT) is initiated for patients with type 2 diabetes mellitus when glycaemic
targets are not met with diet and other hypoglycaemic agents. The initiation of IT improves …

Evolution in medicine is generally driven by clinical need, hand in hand with opportunities
generated by novel chemical and mechanical engineering technologies. Since 1921 that …

This supplement of Pediatric Diabetes is an update of the guideline chapters that were
originally individually published in the journal between 2006 and 2008, and as a single …

Dual activation of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-
1R) has the potential to lead to an effective therapy for the treatment of diabetes and obesity …

In this review, we bring our personal experiences to showcase insulin from its breakthrough
discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and …