Scoliosis is a common spinal deformity that considerably affects the physical and
psychological health of patients. Studies have shown that genetic factors play an important …

During vertebrate embryonic development, a population of dorsal neural tube-derived stem
cells, termed the neural crest (NC), undergo a series of morphogenetic changes and …

Background Axenfeld-Rieger syndrome (ARS) is characterised by typical anterior segment
anomalies, with or without systemic features. The discovery of causative genes identified …

The zebrafish is amenable to a variety of genetic approaches. However, lack of conditional
deletion alleles limits stage-or cell-specific gene knockout. Here, we applied an existing …

Glaucoma refers to a heterogenous group of disorders characterised by progressive loss of
retinal ganglion cells and associated visual field loss. Both early‐onset and adult‐onset …

Axenfeld–Rieger syndrome (ARS) encompasses a group of developmental disorders that
affect the anterior segment of the eye, as well as systemic developmental defects in some …

Glaucoma is a complex and multifactorial disease defined as the loss of retinal ganglion
cells (RGCs) and their axons. Besides an elevated intraocular pressure (IOP), other …

The anterior segment is a critical component of the visual system. Developing independent
of the retina, the AS relies partially on cranial neural crest cells (cNCC) as its earliest …

FOXC1 encodes a forkhead-domain transcription factor associated with several ocular
disorders. Correct FOXC1 dosage is critical to normal development, yet the mechanisms …

Congenital heart defects (CHDs) are common human birth defects. Genetic mutations
potentially cause the exhibition of various pathological phenotypes associated with CHDs …