Abstract Spilanthol (C14H23NO, 221.339 g/mol) is a bioactive compound that is found in
many different plants that are used as traditional remedies throughout the world. It is present …

ABSTRACT Acmella oleracea (L.) RK Jansen belongs to the family Asteraceae is generally
called “toothache plant”. Though Acmella genus has complex patterns, the cylindrical …

Despite advances in medicine and numerous agents that counteract pain, millions of
patients continue to suffer. Attention has been given to identify novel botanical interventions …

Alkamides are natural products formed by connecting straight-chain, mostly unsaturated,
aliphatic acids with various amines by an amide linkage. More than 300 derivatives are …

Purpose To evaluate the efficacy of a new food-grade lecithin formulation of standardized
extracts of Zingiber officinale and Acmella oleracea on pain and inflammation. Patients and …

Purpose To develop an anesthetic mucoadhesive film containing Acmella oleracea (jambu)
extract for topical use on oral mucosa. Methods Ethanolic extracts from aerial parts of jambu …

Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids,
gabapentinoids, opioids, and antidepressants, in this study we address the natural …

Heliopsis longipes roots have been widely used in Mexican traditional medicine to relieve
pain, mainly, toothaches. Previous studies have shown that affinin, the major alkamide of …

Abstract Background: In Mexico, the Asteraceae are part of traditional knowledge where its
members have several uses, but they are particularly remarkable in traditional medicine and …

Acmella oleracea (jambu), is used as ingredient for food and in folk medicine to relief
toothache. Jambu edible flowers are rich in alkylamides, mainly spilanthol, which are …