Construction of a Waddington-like landscape model that can guide clinical exploration of p53-dynamics-activating parameters in the face of divergent p53 dynamics
G Demirkıran - Communications in Nonlinear Science and Numerical …, 2024 - Elsevier
The primary strategy of radiotherapies is to manipulate cell fate decision, a process mainly
regulated by a spectrum of p53 dynamics. Based on their biological relevance, we …
regulated by a spectrum of p53 dynamics. Based on their biological relevance, we …
Piecewise parametric chaotic model of p53 network based on the identified unifying framework of divergent p53 dynamics
G Demirkıran - Chaos, Solitons & Fractals, 2022 - Elsevier
Being the core of the large p53 protein (cancer) network, the ATM-p53-Wip1 sub-network is
known to confer monostable oscillations and fixed levels of p53 to the p53 network. Using a …
known to confer monostable oscillations and fixed levels of p53 to the p53 network. Using a …
Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root‐locus method
Most of the biological systems including gene regulatory networks can be described well by
ordinary differential equation models with rational non‐linearities. These models are derived …
ordinary differential equation models with rational non‐linearities. These models are derived …
Quantifying Information of Dynamical Biochemical Reaction Networks
Z Jiang, YH Su, H Yin - Entropy, 2023 - mdpi.com
A large number of complex biochemical reaction networks are included in the gene
expression, cell development, and cell differentiation of in vivo cells, among other …
expression, cell development, and cell differentiation of in vivo cells, among other …
Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon
G Demirkıran, G Kalaycı Demir… - IET Systems …, 2020 - Wiley Online Library
Double‐strand break‐induced (DSB) cells send signal that induces DSBs in neighbour cells,
resulting in the interaction among cells sharing the same medium. Since p53 network gives …
resulting in the interaction among cells sharing the same medium. Since p53 network gives …
Imaging the Cell Fate based on the Concept of Apoptogram
G Demirkıran - … 11th International Conference on Electrical and …, 2019 - ieeexplore.ieee.org
This study investigates cell fate selection in a single cell by carrying out theoretical analysis
on a parametric 2-Dimensional model. The investigated model involves eight fixed …
on a parametric 2-Dimensional model. The investigated model involves eight fixed …