Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects

G El-Saber Batiha, A Alqahtani, OB Ilesanmi, AA Saati… - Pharmaceuticals, 2020 - mdpi.com
Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …

Chemical control and insecticide resistance status of sand fly vectors worldwide

S Balaska, EA Fotakis, A Chaskopoulou… - PLoS Neglected …, 2021 - journals.plos.org
Background Phlebotomine sand flies are prominent vectors of Leishmania parasites that
cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities …

Streptomyces derivatives as an insecticide: Current perspectives, challenges and future research needs for mosquito control

ZH Amelia-Yap, AS Azman, S AbuBakar, VL Low - Acta Tropica, 2022 - Elsevier
The pervasiveness of arboviruses in wreaking havoc on public health has lingered on
international health agendas. A scarcity of mosquito-borne disease vaccines and therapies …

Ivermectin: a promising therapeutic for fighting malaria. Current status and perspective

L Singh, K Singh - Journal of Medicinal Chemistry, 2021 - ACS Publications
Finding new chemotherapeutic interventions to treat malaria through repurposing of time-
tested drugs and rigorous design of new drugs using tools of rational drug design remains …

Residual malaria: limitations of current vector control strategies to eliminate transmission in residual foci

MH Rodriguez - The Journal of infectious diseases, 2021 - academic.oup.com
The transmission of Plasmodium parasites in residual foci is currently a major roadblock for
malaria elimination. Human activities and behavior, along with outdoor biting mosquitoes …

Spatial parasitology and the unmapped human helminthiases

CG Schluth, CJ Standley, S Bansal, CJ Carlson - Parasitology, 2023 - cambridge.org
Helminthiases are a class of neglected tropical diseases that affect at least 1 billion people
worldwide, with a disproportionate impact on resource-poor areas with limited disease …

Malaria-Transmitting Vectors Microbiota: Overview and Interactions With Anopheles Mosquito Biology

OY Djihinto, AA Medjigbodo, ARA Gangbadja… - Frontiers in …, 2022 - frontiersin.org
Malaria remains a vector-borne infectious disease that is still a major public health concern
worldwide, especially in tropical regions. Malaria is caused by a protozoan parasite of the …

Effect of Ivermectin® on survivorship and fertility of Anopheles arabiensis in Ethiopia: an in vitro study

K Eba, T Habtewold, L Asefa, T Degefa, D Yewhalaw… - Malaria Journal, 2023 - Springer
Background Innovative vector control tools are needed to counteract insecticide resistance
and residual malaria transmission. One of such innovative methods is an ivermectin (IVM) …

The use of molecular xenomonitoring for surveillance of mosquito-borne diseases

MM Cameron, A Ramesh - Philosophical Transactions of …, 2021 - royalsocietypublishing.org
The scientific community recognizes that molecular xenomonitoring (MX) can allow infected
mosquitoes to serve as a proxy for human infection in vector-borne disease surveillance, but …

Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial

HM Soumare, ED Dabira, MM Camara, L Jadama… - Parasites & vectors, 2022 - Springer
Background Vector control interventions in sub-Saharan Africa rely on insecticide-treated
nets and indoor residual spraying. Insecticide resistance, poor coverage of interventions …