This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …

Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …

The dynamic variation of the expression profile and spatial landscape of multiple enzymes
are crucial factors influencing tumor progression and drug treatment. However, the …

G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation.
Despite the important roles that G-quadruplexes play in telomere biology and gene …

A major challenge for distinguishing cancer-causing driver mutations from inconsequential
passenger mutations is the long-tail of infrequently mutated genes in cancer genomes. Here …

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the …

Formation of G-quadruplex (G4) DNA structures in key regulatory regions in the genome has
emerged as a secondary structure-based epigenetic mechanism for regulating multiple …

Significance: For a healthy cell to turn into a cancer cell and grow out to become a tumor, it
needs to undergo a series of complex changes and acquire certain traits, summarized as …

Telomeres (TLs) play major roles in stabilizing the genome and are usually shortened with
ageing. The maintenance of TLs is ensured by two mechanisms involving telomerase (TA) …

Oxidative damage to telomere DNA compromises telomere integrity. We recently reported
that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere …