The current evidence on statin use and prostate cancer prevention: are we there yet?

MA Alfaqih, EH Allott, RJ Hamilton… - Nature Reviews …, 2017 - nature.com
An increasing amount of data supports an inverse association between statin use and
cancer risk. The findings for prostate cancer, particularly advanced disease, are the most …

Targeting lipid metabolism in metastatic prostate cancer

T Scheinberg, B Mak, L Butler… - … Advances in Medical …, 2023 - journals.sagepub.com
Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …

Association of Statin Use with the Risk of Incident Prostate Cancer: A Meta‐Analysis and Systematic Review

MY Xu, Y An, CQ Liu, JZ Xu, XY Zhong… - Journal of …, 2022 - Wiley Online Library
Background. With the growth and aging of population, the incidence of prostate cancer will
increase year by year, which is bound to bring greater economic burden to the society …

Statins: protectors or pretenders in prostate cancer?

H Moon, MM Hill, MJ Roberts, RA Gardiner… - Trends in Endocrinology …, 2014 - cell.com
The role of statin therapy in prostate cancer (PCa) prevention and treatment is plagued by
controversy. This critical review of published clinical series reveals several caveats in earlier …

New insights into lipid metabolism and prostate cancer

Z Zhang, W Wang, P Kong, K Feng… - International …, 2023 - spandidos-publications.com
Prostate cancer (PCa) is the most common malignant tumor of the male urological system
and poses a severe threat to the survival of middle‑aged and elderly males worldwide. The …

LDL-lowering therapy and the risk of prostate cancer: a meta-analysis of 6 randomized controlled trials and 36 observational studies

P Tan, S Wei, Z Tang, L Gao, C Zhang, P Nie… - Scientific Reports, 2016 - nature.com
The role of statins in preventing prostate cancer is currently a controversial issue. The aim of
this review is to investigate the effects of statins use on prostate cancer risk. Electronic …

Inhibition of scavenger receptor class B type 1 (SR-B1) expression and activity as a potential novel target to disrupt cholesterol availability in castration-resistant …

M Pandey, G Cuddihy, JA Gordon, ME Cox, KM Wasan - Pharmaceutics, 2021 - mdpi.com
There have been several studies that have linked elevated scavenger receptor class b type
1 (SR-B1) expression and activity to the development and progression of castration-resistant …

[HTML][HTML] Simvastatin enhances irinotecan-induced apoptosis in prostate cancer via inhibition of MCL-1

MAY Alqudah, HT Mansour, N Mhaidat - Saudi Pharmaceutical Journal, 2018 - Elsevier
Prostate cancer is one of the most common malignant tumors around the world.
Hyperlipidemia is considered as one of the most important risk factors for the development of …

[HTML][HTML] Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase

A Göbel, S Pählig, A Motz, D Breining, S Traikov… - Biochemical and …, 2024 - Elsevier
Prostate cancer is the most prevalent malignancy in men. While diagn ostic and therapeutic
interventions have substantially improved in recent years, disease relapse, treatment …

The effect of statin use on the incidence of prostate cancer: A population‐based nested case–control study

DE Dawe, X Ye, P Czaykowski, D Jassal… - … Journal of Cancer, 2018 - Wiley Online Library
Preclinical studies suggest statins may help prevent prostate cancer (PC), but epidemiologic
results are mixed. Many epidemiological studies have relatively short prediagnosis drug …