[HTML][HTML] The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions
TJ Littlejohns, J Holliday, LM Gibson, S Garratt… - Nature …, 2020 - nature.com
UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …
[HTML][HTML] APOE in the normal brain
SA Flowers, GW Rebeck - Neurobiology of disease, 2020 - Elsevier
The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …
Associations between vascular risk factors and brain MRI indices in UK Biobank
Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …
[HTML][HTML] Structural brain imaging correlates of general intelligence in UK Biobank
The associations between indices of brain structure and measured intelligence are unclear.
This is partly because the evidence to-date comes from mostly small and heterogeneous …
This is partly because the evidence to-date comes from mostly small and heterogeneous …
[HTML][HTML] Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging
A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …
[HTML][HTML] Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: the Lothian Birth Cohort 1936
Discovering why some people's cognitive abilities decline more than others is a key
challenge for cognitive ageing research. The most effective strategy may be to address …
challenge for cognitive ageing research. The most effective strategy may be to address …
[HTML][HTML] The association between white matter hyperintensities and amyloid and tau deposition
White matter hyperintensities (WMHs) frequently occur in Alzheimer's Disease (AD) and
have a contribution from ischemia, though their relationship with β-amyloid and …
have a contribution from ischemia, though their relationship with β-amyloid and …
Women's brain aging: Effects of sex‐hormone exposure, pregnancies, and genetic risk for Alzheimer's disease
Sex hormones such as estrogen fluctuate across the female lifespan, with high levels during
reproductive years and natural decline during the transition to menopause. Women's …
reproductive years and natural decline during the transition to menopause. Women's …
[HTML][HTML] Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study
Abstracts Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk
factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels …
factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels …
[HTML][HTML] Associations of cigarette smoking with gray and white matter in the UK Biobank
Cigarette smoking is associated with increased risk for myriad health consequences
including cognitive decline and dementia, but research on the link between smoking and …
including cognitive decline and dementia, but research on the link between smoking and …