Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

The selective clearance of organelles by autophagy is critical for the regulation of cellular
homeostasis in organisms from yeast to humans. Removal of damaged organelles clears …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Cellular stress, induced by external or internal cues, activates several well-orchestrated
processes aimed at either restoring cellular homeostasis or committing to cell death. Those …

Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded
protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …