1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …

Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range
of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction …

Reactions that enable selective functionalization of strong aliphatic C–H bonds open new
synthetic paths to rapidly increase molecular complexity and expand chemical space …

Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the
last years, offering modern strategies for reaching high molecular complexity in a step-and …

Site selectivity and stereocontrol remain major challenges in C–H bond functionalization
chemistry, especially in linear aliphatic saturated hydrocarbon scaffolds. We report the …

The achievement of sufficient substrate–metal catalyst affinity is a fundamental challenge for
the development of synthetically useful C–H activation reactions of weakly coordinating …

The selective functionalization of C–H bonds is an extremely important topic in present-day
organic synthesis, as it utilizes the most abundant portion of a molecule as a tool for …