Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR

T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

[HTML][HTML] Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR

ASL Thankamony, JJ Wittmann, M Kaushik… - Progress in nuclear …, 2017 - Elsevier
The field of dynamic nuclear polarization has undergone tremendous developments and
diversification since its inception more than 6 decades ago. In this review we provide an in …

Biomolecular and biological applications of solid-state NMR with dynamic nuclear polarization enhancement

WY Chow, G De Paëpe, S Hediger - Chemical Reviews, 2022 - ACS Publications
Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy

JH Ardenkjaer‐Larsen, GS Boebinger… - Angewandte Chemie …, 2015 - Wiley Online Library
In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …

Direct observation of hierarchical protein dynamics

JR Lewandowski, ME Halse, M Blackledge, L Emsley - Science, 2015 - science.org
One of the fundamental challenges of physical biology is to understand the relationship
between protein dynamics and function. At physiological temperatures, functional motions …

Dynamic nuclear polarization NMR spectroscopy of microcrystalline solids

AJ Rossini, A Zagdoun, F Hegner… - Journal of the …, 2012 - ACS Publications
Dynamic nuclear polarization (DNP) solid-state NMR has been applied to powdered
microcrystalline solids to obtain sensitivity enhancements on the order of 100. Glucose …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

[PDF][PDF] Rapid natural-abundance 2D 13 C-13 C correlation spectroscopy using dynamic nuclear polarization enhanced solid-state NMR and matrix-free sample …

H Takahashi, D Lee, L Dubois, M Bardet… - Angewandte …, 2012 - hal.science
Solid-state nuclear magnetic resonance (SSNMR) has been extensively used to
characterize molecular structures at atomic scales.[1] Concerning biomolecular applications …

Mechanisms of dynamic nuclear polarization in insulating solids

TV Can, QZ Ni, RG Griffin - Journal of Magnetic Resonance, 2015 - Elsevier
Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensities in
NMR experiments by transferring the high polarization of electrons to their surrounding …

High-field dynamic nuclear polarization

B Corzilius - Annual review of physical chemistry, 2020 - annualreviews.org
Dynamic nuclear polarization (DNP) is one of the most prominent methods of sensitivity
enhancement in nuclear magnetic resonance (NMR). Even though solid-state DNP under …