Challenges in scaling up AAV-based gene therapy manufacturing
Z Jiang, PA Dalby - Trends in Biotechnology, 2023 - cell.com
Accelerating the scale up of adeno-associated virus (AAV) manufacture is highly desirable
to meet the increased demand for gene therapies. However, the development of …
to meet the increased demand for gene therapies. However, the development of …
Advances and opportunities in process analytical technologies for viral vector manufacturing
SA Sripada, M Hosseini, S Ramesh, J Wang… - Biotechnology …, 2024 - Elsevier
Viral vectors are an emerging, exciting class of biologics whose application in vaccines,
oncology, and gene therapy has grown exponentially in recent years. Following first …
oncology, and gene therapy has grown exponentially in recent years. Following first …
Effect of silencing SSB1 gene on the expression of NBS1 in irradiated rat submandibular gland cells
L Gao, Q Lv, Y Huang, Y Fan, L Zhao… - Cellular and …, 2024 - mail.cellmolbiol.org
The salivary gland (SGS) is a kind of organ vulnerable to ionizing radiation. Radiotherapy is
an important treatment for head and neck tumors, but in the process of radiotherapy, tumor …
an important treatment for head and neck tumors, but in the process of radiotherapy, tumor …
Optimizing high-throughput viral vector characterization with density gradient equilibrium analytical ultracentrifugation
SM Sternisha, AD Wilson, E Bouda… - European Biophysics …, 2023 - Springer
Viral vector-based gene therapies and vaccines require accurate characterization of capsid
species. The current gold standard for assessing capsid loading of adeno-associated virus …
species. The current gold standard for assessing capsid loading of adeno-associated virus …