Prenatal developmental origins of future psychopathology: mechanisms and pathways

C Monk, C Lugo-Candelas… - Annual review of clinical …, 2019 - annualreviews.org
The developmental origins of health and disease hypothesis applied to neurodevelopmental
outcomes asserts that the fetal origins of future development are relevant to mental health …

Sleep deprivation and circadian disruption: stress, allostasis, and allostatic load

BS McEwen, IN Karatsoreos - Sleep medicine clinics, 2015 - sleep.theclinics.com
Anecdotally, there can be little doubt that sleep plays a role in maintaining a good mood and
cognitive acuity. Sleep deprivation one night followed by “getting a good night's sleep” on …

[HTML][HTML] Sleep loss can cause death through accumulation of reactive oxygen species in the gut

A Vaccaro, YK Dor, K Nambara, EA Pollina, C Lin… - Cell, 2020 - cell.com
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

Protective and damaging effects of stress mediators: central role of the brain

BS McEwen - Dialogues in clinical neuroscience, 2006 - Taylor & Francis
The mind involves the whole body, and two-way communication between the brain and the
cardiovascular, immune, and other systems via neural and endocrine mechanisms. Stress is …

Oxidative stress, inflammation, and neuroprogression in chronic PTSD

MW Miller, AP Lin, EJ Wolf… - Harvard review of …, 2018 - journals.lww.com
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in
response to a traumatic event. Many individuals who initially develop the disorder go on to …

Sleep deprivation and oxidative stress in animal models: a systematic review

G Villafuerte, A Miguel-Puga… - Oxidative medicine …, 2015 - Wiley Online Library
Because the function and mechanisms of sleep are partially clear, here we applied a meta‐
analysis to address the issue whether sleep function includes antioxidative properties in …

Sleep duration, cognitive decline, and dementia risk in older women

JC Chen, MA Espeland, RL Brunner, LC Lovato… - Alzheimer's & …, 2016 - Elsevier
Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive
impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on …

Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load

BS McEwen - Metabolism, 2006 - Elsevier
Sleep has important homeostatic functions, and sleep deprivation is a stressor that has
consequences for the brain, as well as many body systems. Whether sleep deprivation is …

A bidirectional relationship between sleep and oxidative stress in Drosophila

VM Hill, RM O'Connor, GB Sissoko, IS Irobunda… - PLoS …, 2018 - journals.plos.org
Although sleep appears to be broadly conserved in animals, the physiological functions of
sleep remain unclear. In this study, we sought to identify a physiological defect common to a …

[HTML][HTML] Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease

J Cedernaes, RS Osorio, AW Varga, K Kam… - Sleep medicine …, 2017 - Elsevier
During wakefulness, extracellular levels of metabolites in the brain increase. These include
amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer's disease (AD) …