Hypoxic environment-responsive nanocarriers represent a promising future in targeted drug
delivery to solid tumors since hypoxia has an important role in tumor proliferation …

Simple Summary Cancer-associated fibroblasts (CAFs) represent an important stromal cell
population of pancreatic cancer in which multiple CAF subtypes have been identified. CAFs …

Simple Summary Hypoxia is a key feature of the tumor microenvironment involved in the
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …

Cancer is the second leading cause of death globally, but conventional anticancer drugs
have side effects, mainly due to their non-specific distribution in the body in both cancerous …

The present work consisted of an exploratory study aiming to evaluate in vitro the potential of
AuNPs during Radiation Therapy (RT) in human pancreatic adenocarcinoma cells. AuNPs …

Solid tumors are composed of a highly complex and heterogenic microenvironment, with
increasing metabolic status. This environment plays a crucial role in the clinical therapeutic …

Various controlled delivery systems (CDSs) have been developed to overcome the
shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.) …

Ferroptosis-based therapy has garnered considerable attention for its ability to kill drug-
resistant cancer cells. Consequently, it holds great significance to assess the therapeutic …

High atomic number (Z) element-based radiosensitizers have been widely reported for
enhancing radiotherapeutic effect, while its limited tumor distribution and long-term safety …

Pancreatic ductal adenocarcinoma (PDAC) has a low survival rate and limited treatment
options. Concurrent chemoradiotherapy is considered beneficial to improve tumor control …