Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Mitochondrial network remodeling between fused and fragmented states facilitates
mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …

Alternative pre-mRNA splicing increases the complexity of the proteome that can be
generated from the available genomic coding sequences. Dysregulation of the splicing …