[HTML][HTML] Redes moleculares: Uma análise sobre anotações e descoberta de novos ativos

AC Pilon, NC Vieira, JG Amaral, AF Monteiro… - Química …, 2021 - SciELO Brasil
MOLECULAR NETWORKS: AN ANALYSIS ON ANNOTATIONS AND DISCOVERY OF NEW
ASSETS. To speed up the discovery of bioactive natural products (NP), chemists have …

Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds

MMP Tangerina, LC Furtado, VMB Leite… - PLoS …, 2020 - journals.plos.org
Resorting to a One Strain Many Compounds (OSMAC) approach, the marine Streptomyces
sp. BRB081 strain was grown in six different media settings over 1, 2, 3 or 7 days …

Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities

CP Tenebro, DJVL Trono, CVB Vicera, EM Sabido… - Scientific reports, 2021 - nature.com
The marine ecosystem has become the hotspot for finding antibiotic-producing
actinomycetes across the globe. Although marine-derived actinomycetes display strain-level …

[HTML][HTML] Anticancer potential of compounds from the Brazilian Blue Amazon

DV Wilke, PC Jimenez, PC Branco… - Planta …, 2021 - thieme-connect.com
“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers
an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline …

Marine Sediment-Derived Streptomyces Strain Produces Angucycline Antibiotics against Multidrug-Resistant Staphylococcus aureus Harboring SCCmec Type 1 …

EM Sabido, CP Tenebro, AFL Suarez… - Journal of Marine …, 2020 - mdpi.com
The Philippine archipelago is geographically positioned in the tropics with rich areas of
marine biodiversity. Its marine sediments harbor actinomycetes that exhibit antibacterial …

Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer

EM Sabido, CP Tenebro, DJVL Trono, CVB Vicera… - Marine Drugs, 2021 - mdpi.com
Marine sediments host diverse actinomycetes that serve as a source of new natural products
to combat infectious diseases and cancer. Here, we report the biodiversity, bioactivities …

The diversity, metabolomics profiling, and the pharmacological potential of actinomycetes isolated from the Estremadura Spur pockmarks (Portugal)

A Pinto-Almeida, A Bauermeister, L Luppino, IR Grilo… - Marine drugs, 2021 - mdpi.com
The Estremadura Spur pockmarks are a unique and unexplored ecosystem located in the
North Atlantic, off the coast of Portugal. A total of 85 marine-derived actinomycetes were …

[PDF][PDF] Application of metabolomics on marine sponges and sponge-associated microorganisms: a review

PO Samirana, RI Jenie, YB Murti… - Journal of Applied …, 2022 - japsonline.com
Sponges and their associated microorganisms have tremendous potential in the medical
world to be explored. However, improper exploration will cause habitat destruction and cost …

Microbial metabolites annotation by mass spectrometry-based metabolomics

PWP Gomes, TC de Tralia Medeiros… - … Products Chemistry: A …, 2023 - Springer
Since the discovery of penicillin, microbial metabolites have been extensively investigated
for drug discovery purposes. In the last decades, microbial derived compounds have gained …

Accessing the specialized metabolome of actinobacteria from the bulk soil of Paullinia cupana Mart. on the Brazilian Amazon: a promising source of bioactive …

NM Maimone, GA Apaza-Castillo, MC Quecine… - Brazilian Journal of …, 2024 - Springer
The Amazon rainforest, an incredibly biodiverse ecosystem, has been increasingly
vulnerable to deforestation. Despite its undeniable importance and potential, the Amazonian …