Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins

N Ramakrishnan, PBS Kumar, R Radhakrishnan - Physics reports, 2014 - Elsevier
Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …

A review of mechanics-based mesoscopic membrane remodeling methods: capturing both the physics and the chemical diversity

G Kumar, SC Duggisetty, A Srivastava - The Journal of Membrane Biology, 2022 - Springer
Specialized classes of proteins, working together in a tightly orchestrated manner, induce
and maintain highly curved cellular and organelles membrane morphology. Due to the …

Multiscale perspectives of virus entry via endocytosis

E Barrow, AV Nicola, J Liu - Virology journal, 2013 - Springer
Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate
infections. Understanding of virus entry via endocytosis is critically important for the design …

Coarse-grained models for protein-cell membrane interactions

R Bradley, R Radhakrishnan - Polymers, 2013 - mdpi.com
The physiological properties of biological soft matter are the product of collective
interactions, which span many time and length scales. Recent computational modeling …

LipidWrapper: an algorithm for generating large-scale membrane models of arbitrary geometry

JD Durrant, RE Amaro - PLoS computational biology, 2014 - journals.plos.org
As ever larger and more complex biological systems are modeled in silico, approximating
physiological lipid bilayers with simple planar models becomes increasingly unrealistic. In …

Model cell membranes: Discerning lipid and protein contributions in shaping the cell

TG Pomorski, T Nylander, M Cárdenas - Advances in colloid and interface …, 2014 - Elsevier
The high complexity of biological membranes has motivated the development and
application of a wide range of model membrane systems to study biochemical and …

Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales

N Ramakrishnan, RP Bradley… - Journal of Physics …, 2018 - iopscience.iop.org
At the micron scale, where cell organelles display an amazing complexity in their shape and
organization, the physical properties of a biological membrane can be better-understood …

Entry modes of ellipsoidal nanoparticles on a membrane during clathrin-mediated endocytosis

H Deng, P Dutta, J Liu - Soft Matter, 2019 - pubs.rsc.org
The membrane wrapping and internalization of nanoparticles, such as viruses and drug
nanocarriers, through clathrin-mediated endocytosis (CME) are vitally important for …

[HTML][HTML] Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness

K Parihar, J Nukpezah, DV Iwamoto, PA Janmey… - Iscience, 2022 - cell.com
Biomechanical signals from remodeled extracellular matrix (ECM) promote tumor
progression. Here, we show that cell-matrix and cell-cell communication may be inherently …