Cardiovascular biomarkers: lessons of the past and prospects for the future

F Omran, I Kyrou, F Osman, VG Lim… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are a major healthcare burden on the population
worldwide. Early detection of this disease is important in prevention and treatment to …

The role of inflammation in cardiovascular outcome

F Montecucco, L Liberale, A Bonaventura… - Current atherosclerosis …, 2017 - Springer
Abstract Purpose of Review The aim of this review is to update the pathophysiological role of
innate immune response in the cardiovascular (CV) disease outcomes, particularly focusing …

Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study

CK Liu, A Lyass, MG Larson, JM Massaro, N Wang… - Age, 2016 - Springer
Cardiovascular disease and frailty frequently occur together. Both are associated with
inflammation, which may be partially triggered by oxidative stress, especially in …

The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases

L Rochette, A Meloux, E Rigal, M Zeller, Y Cottin… - Pharmacology & …, 2018 - Elsevier
Among the numerous molecules that are being studied for their potential utility as
biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of …

Bone metabolism and RANKL/OPG ratio in rheumatoid arthritis women treated with TNF-α inhibitors

A Jura-Półtorak, A Szeremeta, K Olczyk… - Journal of clinical …, 2021 - mdpi.com
The aim of this study was to evaluate the effect of anti-tumor necrosis factor α (anti-TNF-α)
therapy in combination with methotrexate on bone remodeling and osteoclastogenesis in …

A systematic review of the circadian rhythm of bone markers in blood

SS Diemar, SS Dahl, AS West, SA Simonsen… - Calcified Tissue …, 2023 - Springer
There exists a marked circadian variation for several bone markers (BM), which is influenced
by endogenous as well as exogenous factors including hormones, physical activity, and …

Osteoprotegerin in cardiometabolic disorders

C Pérez de Ciriza, A Lawrie… - International journal of …, 2015 - Wiley Online Library
Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has
been recently related to cardiovascular disease (CVD). Human studies show a positive …

Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases

M Dutka, R Bobiński, W Wojakowski, T Francuz… - Heart Failure …, 2022 - Springer
Osteoprotegerin (OPG) is a glycoprotein involved in the regulation of bone remodelling.
OPG regulates osteoclast activity by blocking the interaction between the receptor activator …

Physiological changes and pathological pain associated with sedentary lifestyle-induced body systems fat accumulation and their modulation by physical exercise

E Verdú, J Homs, P Boadas-Vaello - International journal of …, 2021 - mdpi.com
A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

Sustained proinflammatory effects of hypoglycemia in people with type 2 diabetes and in people without diabetes

CEM Verhulst, JIP van Heck, TW Fabricius… - Diabetes, 2022 - Am Diabetes Assoc
Iatrogenic hypoglycemia activates the immune system and is associated with an increased
risk for atherosclerotic disease. We determined acute and long-term effects of insulin …