Complicated role of post-translational modification and protease-cleaved fragments of tau in Alzheimer's Disease and other tauopathies
J Yang, N Shen, J Shen, Y Yang, HL Li - Molecular Neurobiology, 2024 - Springer
Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …
Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice
L La Barbera, A Nobili, E Cauzzi, I Paoletti… - Molecular …, 2022 - Springer
Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …
[HTML][HTML] Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease
What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …
remains to be elucidated and this is one reason why effective AD treatments are missing …
Recent advances towards diagnosis and therapeutic fingerprinting for Alzheimer's disease
Since the report of “a peculiar severe disease process of the cerebral cortex” by Alois
Alzheimer in 1906, it was considered to be a rare condition characterized by loss of …
Alzheimer in 1906, it was considered to be a rare condition characterized by loss of …
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's …
V Latina, G Giacovazzo, F Cordella… - Acta Neuropathologica …, 2021 - Springer
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer's Disease
(AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein …
(AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein …
Focusing on altered neuronal networks to fight early deficits in a mouse model of Alzheimer's Disease
I Paoletti - 2024 - iris.unicampus.it
Although the most accredited hypothesis of neurodegeration is still based on the toxicity
induced by amyloid plaques, there are still no effective therapeutic options for the treatment …
induced by amyloid plaques, there are still no effective therapeutic options for the treatment …