The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases
Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …
diseases. To provide a better understanding of the mechanism and treatment of …
IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …
diseases. The recruitment and activation of both resident microglia and recruited …
C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration
T Yednock, DS Fong, EM Lad - International Journal of Retina and …, 2022 - Springer
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal
neurodegenerative disorder. Human genetic data support the complement system as a key …
neurodegenerative disorder. Human genetic data support the complement system as a key …
[HTML][HTML] Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration
R Natoli, N Fernando, H Jiao, T Racic… - … & visual science, 2017 - tvst.arvojournals.org
Purpose: Complement system dysregulation is strongly linked to the progression of age-
related macular degeneration (AMD). Deposition of complement including C3 within the …
related macular degeneration (AMD). Deposition of complement including C3 within the …
Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Background Inflammasome activation and the subsequent release of pro-inflammatory
cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the …
cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the …
Cholesterol homeostasis in the vertebrate retina: biology and pathobiology
SR Rao, SJ Fliesler - Journal of lipid research, 2021 - ASBMB
Cholesterol is a quantitatively and biologically significant constituent of all mammalian cell
membrane, including those that comprise the retina. Retinal cholesterol homeostasis entails …
membrane, including those that comprise the retina. Retinal cholesterol homeostasis entails …
Small-medium extracellular vesicles and their miRNA cargo in retinal health and degeneration: mediators of homeostasis, and vehicles for targeted gene therapy
Photoreceptor cell death and inflammation are known to occur progressively in retinal
degenerative diseases such as age-related macular degeneration (AMD). However, the …
degenerative diseases such as age-related macular degeneration (AMD). However, the …
Toll-like receptor 2 facilitates oxidative damage-induced retinal degeneration
Retinal degeneration is a form of neurodegenerative disease and is the leading cause of
vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate …
vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate …
[HTML][HTML] Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration
Rationale: Müller cells play an essential role in maintaining the health of retinal
photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor …
photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor …
[HTML][HTML] MicroRNA-124 dysregulation is associated with retinal inflammation and photoreceptor death in the degenerating retina
JA Chu-Tan, M Rutar, K Saxena… - … & visual science, 2018 - arvojournals.org
Purpose: We sought to determine the role and retinal cellular location of microRNA-124
(miR-124) in a neuroinflammatory model of retinal degeneration. Further, we explored the …
(miR-124) in a neuroinflammatory model of retinal degeneration. Further, we explored the …