Mechanisms of Polycomb group protein function in cancer
V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
[HTML][HTML] Regulation and role of EZH2 in cancer
H Yamaguchi, MC Hung - Cancer research and treatment …, 2014 - synapse.koreamed.org
Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …
[HTML][HTML] SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways
H Yuan, Y Han, X Wang, N Li, Q Liu, Y Yin, H Wang… - Cancer cell, 2020 - cell.com
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
Post-translational modifications of EZH2 in cancer
Z Li, M Li, D Wang, P Hou, X Chen, S Chu, D Chai… - Cell & bioscience, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
The potential role of MicroRNA-124 in cerebral ischemia injury
X Liu, Z Feng, L Du, Y Huang, J Ge, Y Deng… - International journal of …, 2019 - mdpi.com
Cerebral ischemia injury, the leading cause of morbidity and mortality worldwide, initiates
sequential molecular and cellular pathologies that underlie ischemic encephalopathy (IE) …
sequential molecular and cellular pathologies that underlie ischemic encephalopathy (IE) …
Smurfs in protein homeostasis, signaling, and cancer
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer
H Yamaguchi, Y Du, K Nakai, M Ding, SS Chang… - Oncogene, 2018 - nature.com
Inhibitors against poly (ADP-ribose) polymerase (PARP) are promising targeted agents
currently used to treat BRCA-mutant ovarian cancer and are in clinical trials for other cancer …
currently used to treat BRCA-mutant ovarian cancer and are in clinical trials for other cancer …
PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression
J Wan, J Zhan, S Li, J Ma, W Xu, C Liu… - Nucleic acids …, 2015 - academic.oup.com
Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator that catalyzes the
trimethylation of H3K27 and is modulated by post-translational modifications (PTMs) …
trimethylation of H3K27 and is modulated by post-translational modifications (PTMs) …
Inhibition of EZH2 (enhancer of zeste homolog 2) attenuates neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (trimethylation of histone 3 lysine 27/suppressor …
Background and Purpose: Neuroinflammation has been proven to play an important role in
the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). EZH2 …
the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). EZH2 …
Post-translational modifications of PRC2: signals directing its activity
Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …