[HTML][HTML] Allergen immunotherapy: past, present and future

SR Durham, MH Shamji - Nature Reviews Immunology, 2023 - nature.com
Allergen immunotherapy is a form of therapeutic vaccination for established IgE-mediated
hypersensitivity to common allergen sources such as pollens, house dust mites and the …

The role of allergen‐specific IgE, IgG and IgA in allergic disease

MH Shamji, R Valenta, T Jardetzky, V Verhasselt… - Allergy, 2021 - Wiley Online Library
Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease
affecting more than 30% of the population. Exposure to even minute quantities of allergens …

Allergen immunotherapy in children user's guide

M Alvaro‐Lozano, CA Akdis, M Akdis… - Pediatric allergy and …, 2020 - Wiley Online Library
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

IgE and IgG antibodies as regulators of mast cell and basophil functions in food allergy

C Kanagaratham, YS El Ansari, OL Lewis… - Frontiers in …, 2020 - frontiersin.org
Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …

[HTML][HTML] Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

MH Shamji, SR Durham - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and
asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical …

Modulating Th2 cell immunity for the treatment of asthma

B León, A Ballesteros-Tato - Frontiers in immunology, 2021 - frontiersin.org
It is estimated that more than 339 million people worldwide suffer from asthma. The leading
cause of asthma development is the breakdown of immune tolerance to inhaled allergens …

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

MH Shamji, JH Kappen, M Akdis, E Jensen‐Jarolim… - Allergy, 2017 - Wiley Online Library
Background Allergen immunotherapy (AIT) is an effective treatment for allergic
rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex …

Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses

S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …

Allergen immunotherapy: a practice parameter third update

L Cox, H Nelson, R Lockey, C Calabria… - Journal of Allergy and …, 2011 - jacionline.org
This document builds on the previous Joint Task Force document ''Allergen immunotherapy:
a practice parameter second update''published in the Journal of Allergy and Clinical …

Oral immunotherapy for treatment of egg allergy in children

AW Burks, SM Jones, RA Wood… - … England Journal of …, 2012 - Mass Medical Soc
Background For egg allergy, dietary avoidance is the only currently approved treatment. We
evaluated oral immunotherapy using egg-white powder for the treatment of children with egg …