Seaweed protein hydrolysates and bioactive peptides: Extraction, purification, and applications

J Echave, M Fraga-Corral, P Garcia-Perez… - Marine drugs, 2021 - mdpi.com
Seaweeds are industrially exploited for obtaining pigments, polysaccharides, or phenolic
compounds with application in diverse fields. Nevertheless, their rich composition in fiber …

Recent applications of light scattering measurement in the biological and biopharmaceutical sciences

AP Minton - Analytical biochemistry, 2016 - Elsevier
Measurement of the average intensity of excess scattering, termed static light scattering
(SLS), has become one of the most widely used techniques for the determination of molar …

IgG charge: practical and biological implications

D Yang, R Kroe-Barrett, S Singh, T Laue - Antibodies, 2019 - mdpi.com
Practically, IgG charge can contribute significantly to thermodynamic nonideality, and hence
to solubility and viscosity. Biologically, IgG charge isomers exhibit differences in clearance …

Comparison of emulsifying properties of plant and animal proteins in oil-in-water emulsions: whey, soy, and RuBisCo proteins

Y Tan, PW Lee, TD Martens, DJ McClements - Food Biophysics, 2022 - Springer
There is increasing interest within the food industry in replacing animal-derived ingredients
with plant-derived alternatives. In this study, we compared the emulsifying properties of an …

Ribosome surface properties may impose limits on the nature of the cytoplasmic proteome

PE Schavemaker, WM Śmigiel, B Poolman - Elife, 2017 - elifesciences.org
Much of the molecular motion in the cytoplasm is diffusive, which possibly limits the tempo of
processes. We studied the dependence of protein mobility on protein surface properties and …

Optothermophoretic flipping method for biomolecule interaction enhancement

J Chen, Y Zeng, J Zhou, X Wang, B Jia, R Miyan… - Biosensors and …, 2022 - Elsevier
The widely used surface-based biomolecule sensing scheme has greatly facilitated the
investigation of protein-protein interactions in lab-on-a-chip microfluidic systems. However …

Application of interpretable artificial neural networks to early monoclonal antibodies development

L Gentiluomo, D Roessner, D Augustijn… - European Journal of …, 2019 - Elsevier
The development of a new protein drug typically starts with the design, expression and
biophysical characterization of many different protein constructs. The initially high number of …

Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization

L Gentiluomo, HL Svilenov, D Augustijn… - Molecular …, 2019 - ACS Publications
Therapeutic protein candidates should exhibit favorable properties that render them suitable
to become drugs. Nevertheless, there are no well-established guidelines for the efficient …

Challenges in predicting protein-protein interactions from measurements of molecular diffusivity

LL Sorret, MA DeWinter, DK Schwartz, TW Randolph - Biophysical journal, 2016 - cell.com
Dynamic light scattering can be used to measure the diffusivity of a protein within a
formulation. The dependence of molecular diffusivity on protein concentration (traditionally …

Optimizing the bioavailability of subcutaneously administered biotherapeutics through mechanochemical drivers

DS Collins, LC Kourtis, NR Thyagarajapuram… - Pharmaceutical …, 2017 - Springer
The subcutaneous route offers myriad benefits for the administration of biotherapeutics in
both acute and chronic diseases, including convenience, cost effectiveness and the …