The rapid development of drug nanocarriers has benefited from the surface hydrophilic
polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene …

Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct
properties by changing the precursors and the flow rates, significantly decreasing the time …

Nanoparticles designed as messenger RNA (mRNA) carriers to deliver gene medicine have
shown great potential to change the way lung disease states are managed. Controlling their …

There is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in
order to improve vehicle stability and reduce toxicity, but little is known about the effects of …

Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …

CRISPR/Cas9 technology enables targeted gene editing; yet, the efficiency and specificity
remain unsatisfactory, particularly for the nonvirally delivered, plasmid‐based CRISPR/Cas9 …

Diosgenin encapsulated PCL-Pluronic nanoparticles (PCL-F68-D-NPs) were developed
using the nanoprecipitation method to improve performance in brain cancer (glioblastoma) …

Ischemic stroke involves pro-inflammatory species, which implicates inflammation in the
disease mechanism. Recent studies indicate that the prevalence of therapeutic choice such …