Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Unsupervised machine learning methods and emerging applications in healthcare

CM Eckhardt, SJ Madjarova, RJ Williams… - Knee Surgery, Sports …, 2023 - Springer
Unsupervised machine learning methods are important analytical tools that can facilitate the
analysis and interpretation of high-dimensional data. Unsupervised machine learning …

An explainable machine learning pipeline for stroke prediction on imbalanced data

C Kokkotis, G Giarmatzis, E Giannakou, S Moustakidis… - Diagnostics, 2022 - mdpi.com
Stroke is an acute neurological dysfunction attributed to a focal injury of the central nervous
system due to reduced blood flow to the brain. Nowadays, stroke is a global threat …

The interplay between symptoms of insomnia and pain in people with osteoarthritis: A narrative review of the current evidence

L De Baets, N Runge, C Labie, O Mairesse… - Sleep Medicine …, 2023 - Elsevier
Osteoarthritis (OA) is a leading cause of disability worldwide and clinical pain is the major
symptom of OA. This clinical OA-related pain is firmly associated with symptoms of insomnia …

[HTML][HTML] Biomarkers for osteoarthritis: Current status and future prospects

A Mobasheri, CS Thudium, AC Bay-Jensen… - Best Practice & …, 2023 - Elsevier
Osteoarthritis (OA) is the most common form of arthritis globally and a major cause of pain,
physical disability, and loss of economic productivity, with currently no causal treatment …

Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

RL Nielsen, T Monfeuga, RR Kitchen, L Egerod… - Nature …, 2024 - nature.com
Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients' lives.
However, our understanding of biomarkers driving OA risk remains limited. We developed a …

Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets

SN Wijesinghe, A Badoume, DE Nanus… - Clinical and …, 2023 - Wiley Online Library
Background Osteoarthritis (OA), a multifaceted condition, poses a significant challenge for
the successful clinical development of therapeutics due to heterogeneity. However …

The application of machine learning in early diagnosis of osteoarthritis: a narrative review

A Xuan, H Chen, T Chen, J Li, S Lu… - Therapeutic …, 2023 - journals.sagepub.com
Osteoarthritis (OA) is the commonest musculoskeletal disease worldwide, with an increasing
prevalence due to aging. It causes joint pain and disability, decreased quality of life, and a …

Apoptosis regulation in osteoarthritis and the influence of lipid interactions

F Werry, E Mazur, LFH Theyse, F Edlich - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is one of the most common chronic diseases in human and animal joints.
The joints undergo several morphological and histological changes during the development …

[HTML][HTML] Osteoarthritis year in review 2023: Metabolite and protein biomarkers

M Liu, N Haque, J Huang, G Zhai - Osteoarthritis and Cartilage, 2023 - Elsevier
Objective To highlight the advances over the past year in metabolite/protein biomarkers for
osteoarthritis (OA). Method A literature search of five databases including PubMed, Web of …