[HTML][HTML] The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of …

SC Shabalala, PV Dludla, L Mabasa, AP Kappo… - Biomedicine & …, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds

A Guru, PK Issac, M Velayutham, NT Saraswathi… - Molecular Biology …, 2021 - Springer
Obesity is growing at an alarming rate, which is characterized by increased adipose tissue. It
increases the probability of many health complications, such as diabetes, arthritis, cardiac …

Natural products to counteract the epidemic of cardiovascular and metabolic disorders

B Waltenberger, A Mocan, K Šmejkal, EH Heiss… - Molecules, 2016 - mdpi.com
Natural products have always been exploited to promote health and served as a valuable
source for the discovery of new drugs. In this review, the great potential of natural …

[HTML][HTML] Current understanding of glucose transporter 4 expression and functional mechanisms

T Wang, J Wang, X Hu, XJ Huang… - World journal of …, 2020 - ncbi.nlm.nih.gov
Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

Polyphenols, autophagy and doxorubicin-induced cardiotoxicity

S Shabalala, CJF Muller, J Louw, R Johnson - Life sciences, 2017 - Elsevier
Doxorubicin is a highly effective, first line chemotherapeutic agent used in the management
of hematological and solid tumors. The effective use of doxorubicin in cancer therapy has …

The potential therapeutic value of medicinal plants in the management of metabolic disorders

TT Nyakudya, T Tshabalala, R Dangarembizi… - Molecules, 2020 - mdpi.com
Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is
associated with an increased risk of developing diabetes and other major cardiovascular …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

PV Dludla, E Joubert, CJF Muller, J Louw… - Nutrition & …, 2017 - Springer
Diabetic patients are at an increased risk of developing heart failure when compared to their
non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be …

Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance by modulating PI3K/AKT and AMPK pathways

SE Mazibuko-Mbeje, PV Dludla, C Roux… - International journal of …, 2019 - mdpi.com
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications

K Ziqubu, PV Dludla, E Joubert, CJF Muller… - Pharmacological …, 2020 - Elsevier
Isoorientin is a natural C-glucosyl flavone that is generating a lot of interest due to its
multiple pharmacological activities. Increasing experimental data have shown that the robust …