The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Modulation of synaptic transmission and brain microcirculation are new roles ascribed to
astrocytes in CNS function. A mechanism by which astrocytes modify neuronal activity in the …

Several new findings have emphasized the role of neuron‐specific gap junction proteins
(connexins) and electrical synapses in processing sensory information and in synchronizing …

Purinergic signaling plays distinct and important roles in the CNS, including the transmission
of calcium signals between astrocytes. Gap junction hemichannels are among the …

Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been
proposed to be the pore induced by P2X7 receptor (P2X7R) activation. We explored the …

The cells of most mammalian organs are connected by groups of cell-to-cell channels called
gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins …

The immature cerebral cortex self-organizes into local neuronal clusters long before it is
activated by patterned sensory inputs. In the cortical anlage of newborn mammals, neurons …

The pancreatic islet is a highly coupled, multicellular system that exhibits complex
spatiotemporal electrical activity in response to elevated glucose levels. The emergent …