Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles
RB Fletcher, LD Stokes, IB Kelly III, KM Henderson… - ACS …, 2023 - ACS Publications
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
Plasma‐Derived Nanoclusters for Site‐Specific Multimodality Photo/Magnetic Thrombus Theranostics
Traditional thrombolytic therapeutics for vascular blockage are affected by their limited
penetration into thrombi, associated off‐target side effects, and low bioavailability, leading to …
penetration into thrombi, associated off‐target side effects, and low bioavailability, leading to …
Dynamic Nuclear Polarization of Selectively 29Si-Enriched Core@shell Silica Nanoparticles
29Si silica nanoparticles (SiO2 NPs) are promising magnetic resonance imaging (MRI)
probes that possess advantageous properties for in vivo applications, including suitable …
probes that possess advantageous properties for in vivo applications, including suitable …
MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review
Cardiovascular disease shows, or may even be caused by, changes in metabolism.
Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could …
Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could …
Hyperpolarized water via dissolution dynamic nuclear polarization: Applications in biomolecular NMR
Although traditional nuclear magnetic resonance (NMR) spectroscopy is essential for
investigating the structures and dynamics of biomolecules, it is impeded by low sensitivity …
investigating the structures and dynamics of biomolecules, it is impeded by low sensitivity …
Hyperpolarized 29 Si magnetic resonance spectroscopy of selectively radical-embedded silica nanoparticles
The embedding of radicals at different locations within core@ shell silica nanoparticles
contributes to enhanced polarization capability and can be self-polarized without adding …
contributes to enhanced polarization capability and can be self-polarized without adding …
Unmasking Fluorinated Moieties on the Surface of Hydride-Terminated Silicon Nanoparticles
Despite the widespread use of hydrofluoric acid (HF) in the preparation of silicon surfaces,
the true nature of fluorinated surface species remains unclear. Here, we employ an array of …
the true nature of fluorinated surface species remains unclear. Here, we employ an array of …
Background free in vivo 29 Si MR imaging with hyperpolarized PEGylated silicon nanoparticles
This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolution in
vivo29Si MR imaging, emphasizing their biocompatibility and water dispersibility. The …
vivo29Si MR imaging, emphasizing their biocompatibility and water dispersibility. The …
Enhanced Solubility and Polarization of 13C-Fumarate with Meglumine Allows for In Vivo Detection of Gluconeogenic Metabolism in Kidneys
MT Huynh, Z Erfani, S Al Nemri, S Chirayil… - … Applied Materials & …, 2024 - ACS Publications
Hyperpolarized 13C-labeled fumarate probes tissue necrosis via the production of 13C-
malate. Despite its promises in detecting tumor necrosis and kidney injuries, its clinical …
malate. Despite its promises in detecting tumor necrosis and kidney injuries, its clinical …
[HTML][HTML] Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis
A new approach to treating vascular blockages has been developed to overcome the
limitations of current thrombolytic therapies. This approach involves biosafety and …
limitations of current thrombolytic therapies. This approach involves biosafety and …