Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

Selenium (Se) is an essential dietary trace element that plays an important role in the
prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins …

Amyloid fibrillar assemblies, originally identified as pathological entities in
neurodegenerative diseases, have been widely adopted by various proteins to fulfill diverse …

The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …

Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the
substantia nigra pars compacta region of the brain and accumulation of aggregated forms of …

Protein misfolding with subsequent formation of cross-β-sheet-rich fibrils is a well-known
pathological hallmark of various neurodegenerative conditions, including Alzheimer's …

Galantamine is a natural alkaloid extracted from the Amaryllidaceae plants and is used as
the active ingredient of a drug approved for the treatment of the early stages of Alzheimer's …

Zinc is the second most abundant trace element in the human body, and it plays a
fundamental role in human physiology, being an integral component of hundreds of …

Recently, a large number of experimenters have found that the pathogenesis of Parkinson's
disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis …