Engineered living materials: prospects and challenges for using biological systems to direct the assembly of smart materials

PQ Nguyen, NMD Courchesne… - Advanced …, 2018 - Wiley Online Library
Vast potential exists for the development of novel, engineered platforms that manipulate
biology for the production of programmed advanced materials. Such systems would possess …

Designing cell function: assembly of synthetic gene circuits for cell biology applications

M Xie, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Programming self-organizing multicellular structures with synthetic cell-cell signaling

S Toda, LR Blauch, SKY Tang, L Morsut, WA Lim - Science, 2018 - science.org
A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

Biological engineered living materials: growing functional materials with genetically programmable properties

C Gilbert, T Ellis - ACS synthetic biology, 2018 - ACS Publications
Natural biological materials exhibit remarkable properties: self-assembly from simple raw
materials, precise control of morphology, diverse physical and chemical properties, self …

[HTML][HTML] Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis

E Izquierdo, T Quinkler, S De Renzis - Nature communications, 2018 - nature.com
During organismal development, cells undergo complex changes in shape whose causal
relationship to individual morphogenetic processes remains unclear. The modular nature of …

[HTML][HTML] A synthetic bacterial cell-cell adhesion toolbox for programming multicellular morphologies and patterns

DS Glass, IH Riedel-Kruse - Cell, 2018 - cell.com
Synthetic multicellular systems hold promise as models for understanding natural
development of biofilms and higher organisms and as tools for engineering complex multi …

Hybrid living materials: digital design and fabrication of 3D multimaterial structures with programmable biohybrid surfaces

RSH Smith, C Bader, S Sharma, D Kolb… - Advanced Functional …, 2020 - Wiley Online Library
Significant efforts exist to develop living/non‐living composite materials—known as
biohybrids—that can support and control the functionality of biological agents. To enable the …

[HTML][HTML] Context-aware synthetic biology by controller design: Engineering the mammalian cell

N Shakiba, RD Jones, R Weiss, D Del Vecchio - Cell systems, 2021 - cell.com
The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …

Cell competition during reprogramming gives rise to dominant clones

N Shakiba, A Fahmy, G Jayakumaran, S McGibbon… - Science, 2019 - science.org
INTRODUCTION Recent advances in lineage tracking using DNA-based barcoding
technologies have provided new insights into the developmental dynamics of cell …

[HTML][HTML] Liquid crystal elastomers for biological applications

M Hussain, EIL Jull, RJ Mandle, T Raistrick, PJ Hine… - Nanomaterials, 2021 - mdpi.com
The term liquid crystal elastomer (LCE) describes a class of materials that combine the
elastic entropy behaviour associated with conventional elastomers with the stimuli …