Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

Simple Summary Cancer cells are dependent on normal cells for their survival and
functionality because they can use nanoscale tubes to steal the mitochondria from immune …

Our understanding of the molecular mechanisms underlying cancer development and
evolution have evolved rapidly over recent years, and the variation from one patient to …

Neoadjuvant therapy is commonly used in patients with locally advanced or inoperable
breast cancer (BC). Neoadjuvant chemotherapy (NACT) represents an established …

Background: Advances in cancer medicines have resulted in tangible health impacts, but the
magnitude of benefits of approved cancer medicines could vary greatly. Health Technology …

Purpose: In JACOB trial, pertuzumab added to trastuzumab-chemotherapy did not
significantly improve survival of patients with HER2-positive metastatic gastric cancer …

Background In the adjuvant setting of cancer treatment, de-escalation strategies have the
goal of omitting or minimizing treatment in patients, without compromising outcomes …

Background Tumor biomarkers are regularly used to guide breast cancer treatment and
clinical trial enrollment. However, there remains a lack of knowledge regarding physicians' …

Circulating tumor DNA (ctDNA) analysis can identify patients with residual disease before it
is clinically or radiologically evident. Minimal residual disease (MRD) is an advancing area …

Purpose To analyze long-term oncological outcome after 2nd conservative treatment (2 nd
CT) for patients with ipsilateral 2nd ipsilateral breast tumor event (2 nd IBTE) …