Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders
MT Kabir, MH Rahman, M Shah, MR Jamiruddin… - Biomedicine & …, 2022 - Elsevier
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
Molecular pathophysiological mechanisms in Huntington's disease
A Jurcau - Biomedicines, 2022 - mdpi.com
Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …
cannabinoids have received growing interest as treatment options in neurodegenerative …
Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction
Background Increased attention has been focused on the associations of periodontal
disease with the onset and progression of cognitive impairment. Although the associations …
disease with the onset and progression of cognitive impairment. Although the associations …
Mitochondrial bioenergy in neurodegenerative disease: Huntington and Parkinson
Strong evidence suggests a correlation between degeneration and mitochondrial deficiency.
Typical cases of degeneration can be observed in physiological phenomena (ie, ageing) as …
Typical cases of degeneration can be observed in physiological phenomena (ie, ageing) as …
Flavonols in action: Targeting oxidative stress and neuroinflammation in major depressive disorder
Major depressive disorder is one of the most common mental illnesses that highly impairs
quality of life. Pharmacological interventions are mainly focused on altered monoamine …
quality of life. Pharmacological interventions are mainly focused on altered monoamine …
Nanotechnology-based drug delivery strategies to repair the mitochondrial function in neuroinflammatory and neurodegenerative diseases
LF González, LE Bevilacqua, R Naves - Pharmaceutics, 2021 - mdpi.com
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological
processes related to energy production, calcium homeostasis, the generation of reactive …
processes related to energy production, calcium homeostasis, the generation of reactive …
Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6
S EdwinaáLucia, J RyunáRyu… - Chemical …, 2023 - pubs.rsc.org
Despite the apparent copious fluorescent probes targeting mitochondria, the development of
low cytotoxic probes is still needed for improving validation of mitochondrial function …
low cytotoxic probes is still needed for improving validation of mitochondrial function …