Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

In-line analysis of organ-on-chip systems with sensors: Integration, fabrication, challenges, and potential

S Fuchs, S Johansson, AØ Tjell, G Werr… - ACS Biomaterials …, 2021 - ACS Publications
Organ-on-chip systems are promising new in vitro research tools in medical,
pharmaceutical, and biological research. Their main benefit, compared to standard cell …

[HTML][HTML] Measurement and analysis of cancer biomarkers based on electrochemical biosensors

F Cui, Z Zhou, HS Zhou - Journal of The Electrochemical Society, 2019 - iopscience.iop.org
Cancer is a dreadful disease with a high mortality rate, and it has become more and more
prevalent worldwide. Early diagnosis, prognosis and treatment monitoring with robust and …

[HTML][HTML] Bone/cartilage organoid on-chip: Construction strategy and application

Y Hu, H Zhang, S Wang, L Cao, F Zhou, Y Jing, J Su - Bioactive Materials, 2023 - Elsevier
The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …

[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development

AG Monteduro, S Rizzato, G Caragnano… - Biosensors and …, 2023 - Elsevier
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

[HTML][HTML] Gut-on-a-chip: Mimicking and monitoring the human intestine

D Marrero, F Pujol-Vila, D Vera, G Gabriel, X Illa… - Biosensors and …, 2021 - Elsevier
Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …

Electrochemical sensing directions for next-generation healthcare: trends, challenges, and frontiers

JF Hernández-Rodríguez, D Rojas… - Analytical …, 2020 - ACS Publications
Unfortunately, last year we have witnessed one of the worst global health crises in recent
history. SARS-COV-2 pandemic outbreak has revealed that global healthcare systems were …

Advances in the Translation of Electrochemical Hydrogel‐Based Sensors

H Shafique, J de Vries, J Strauss… - Advanced …, 2023 - Wiley Online Library
Novel biomaterials for bio‐and chemical sensing applications have gained considerable
traction in the diagnostic community with rising trends of using biocompatible and lowly …

[HTML][HTML] Intensive care unit-acquired weakness: not just another muscle atrophying condition

H Lad, TM Saumur, MS Herridge… - International journal of …, 2020 - mdpi.com
Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …

[HTML][HTML] Advancement of sensor integrated organ-on-chip devices

GA Clarke, BX Hartse, AE Niaraki Asli, M Taghavimehr… - Sensors, 2021 - mdpi.com
Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds
much hope since they arrived and began to grow in sophistication. However, limitations for …