The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Abstract Approximately 20–30% of PCOS women demonstrate excess adrenal precursor
androgen (APA) production, primarily using DHEAS as a marker of APA in general and more …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Genome-wide association studies of birth weight have focused on fetal genetics, whereas
relatively little is known about the role of maternal genetic variation. We aimed to identify …

Xenobiotics have been defined as chemicals to which an organism is exposed that are
extrinsic to the normal metabolism of that organism. Without metabolism, many xenobiotics …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory
mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified …

Today's drug therapy regimens rely on the anticipated relation between drug dose, acquired
plasma level and desired effect. However, the capacity of individual patients to absorb and …