Polymorphism rs143384 GDF5 reduces the risk of knee osteoarthritis development in obese individuals and increases the disease risk in non-obese population

V Novakov, O Novakova, M Churnosova, I Aristova… - Arthroplasty, 2024 - Springer
Background We investigated the effect of obesity on the association of genome-wide
associative studies (GWAS)-significant genes with the risk of knee osteoarthritis (KOA) …

Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer Risk in Caucasian Women of Russia

I Ponomarenko, K Pasenov, M Churnosova… - International Journal of …, 2024 - mdpi.com
In our work, the associations of GWAS (genome-wide associative studies) impact for sex-
hormone-binding globulin (SHBG)-level SNPs with the risk of breast cancer (BC) in the …

Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk

E Reshetnikov, M Churnosova, Y Reshetnikova… - International Journal of …, 2024 - mdpi.com
We aimed to explore the potential link of maternal age at menarche (mAAM) gene
polymorphisms with risk of the fetal growth restriction (FGR). This case (FGR)–control (FGR …

Obesity-Dependent Association of the rs10454142 PPP1R21 with Breast Cancer

I Ponomarenko, K Pasenov, M Churnosova, I Sorokina… - Biomedicines, 2024 - mdpi.com
The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex
hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was …

SUMMIT-FA: a new resource for improved transcriptome imputation using functional annotations

HJ Melton, Z Zhang, C Wu - Human molecular genetics, 2024 - academic.oup.com
Transcriptome-wide association studies (TWAS) integrate gene expression prediction
models and genome-wide association studies (GWAS) to identify gene-trait associations …

Population Structure Dynamics of Belgorod Oblast: Ethnic Composition

KN Sergeeva, SN Sokorev, YI Goncharova… - Russian Journal of …, 2024 - Springer
The results of an analysis of the dynamics of the ethnicity of spouses in Belgorod oblast from
1890–1910 to 2016–2018 are presented. A fairly homogeneous ethnic composition has …

Maternal age at menarche gene polymorphisms are associated with offspring birth weight

Y Reshetnikova, M Churnosova, V Stepanov… - Life, 2023 - mdpi.com
In this study, the association between maternal age at menarche (AAM)-related
polymorphisms and offspring birth weight (BW) was studied. The work was performed on a …