Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

Extensive research in the past decade has identified innate immune recognition receptors
and intracellular signaling pathways that culminate in inflammatory responses. Besides its …

The neutrophil is a key player in immunity, and its activities are essential for the resolution of
infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial …

The presence of two dedicated phagocytic cells working cooperatively represents an
advantageous innate immune strategy that allows the efficient and safe utilization of …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

The mechanisms of chronic infections caused by opportunistic pathogens are of keen
interest to both researchers and health professionals globally. Typically, chronic infectious …

Reactive oxygen species (ROS) have long been studied in the context of their direct toxic
effects on cells. As a result, ROS have conventionally been thought of as a necessary …

Francisella tularensis subverts the immune system to rapidly grow within mammalian hosts,
often causing tularemia, a fatal disease. This pathogen targets the cytosol of macrophages …