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Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

Localized radiotherapy (RT) induces an immunogenic antitumor response that is in part
counterbalanced by activation of immune evasive and tissue remodeling processes, eg, via …

Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the
causal involvement of senescence in aging and offer therapeutic interventions. Here we …

Background Radiotherapy outcomes are limited by toxicity in the healthy tissues
surrounding the irradiated tumor. Recent pre-clinical studies have shown that irradiations …

Purpose: One of the main limitations to anticancer radiotherapy lies in irreversible damage
to healthy tissues located within the radiation field.“FLASH” irradiation at very high dose-rate …

In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …