Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high
morbidity and mortality, leading to almost half-million deaths annually worldwide. A better …

Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the
most resistant to treatment. The survival rate of HNSCC patients has been still very low since …

Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral
cavity having premalignant potential and unclear pathogenesis. Recently, myofibroblast has …

Background To immunohistochemically evaluate the association between the presence of
cancer-associated fibroblasts (CAFs) and the tumour expression of podoplanin (PDPN) in …

In recent decades, understanding tumorigenesis and the complex interaction between the
host and the immune system has been the pillar for significant advances in anticancer …

Abstract Background Cancer-associated fibroblasts (CAFs) are major players in tumor-
stroma communication, and participate in several cancer hallmarks to drive tumor …

Aims and Objectives: Squamous cell carcinoma (SCC) is a common oral malignancy with a
poor survival rate. Early tumorigenesis is marked by transdifferentiation of fibroblasts to …

Fibroblasts are the most abundant cellular components of connective tissue. They possess
phenotypical heterogenicity and may be present in the form of smooth muscle cells or …

The aim of the present study was to investigate the tropism of mesenchymal stem cells
(MSCs) to the tumor microenvironment, and to evaluate the feasibility of bone marrow …

Background: Oral submucous fibrosis (OSF) is a precancerous lesion, with oral squamous
cell carcinoma (OSCC) being the most prevalent malignancy affecting the oral mucosa. The …