The accelerating and thorough treatment of chronic wounds still represents a major unmet
medical need owing to the complex symptoms resulting from metabolic disorder of the …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

The spatial presentation of mechanical information is a key parameter for cell behavior. We
have developed a method of polymerization control in which the differential diffusion …

Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix.
Recently, it has been proposed that in addition to matrix stiffness and ligand type, the degree …

The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …

Decellularized extracellular matrices (dECMs) have demonstrated excellent utility as
bioscaffolds in recapitulating the complex biochemical microenvironment, however, their use …

Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …

Hydrogels are polymeric materials distinguished by high water content and diverse physical
properties. They can be engineered to resemble the extracellular environment of the body's …

Hydrogels prepared from natural polymers have received immense considerations over the
past decade due to their safe nature, biocompatibility, hydrophilic properties, and …