Cancer cells have fundamentally altered cellular metabolism that is associated with their
tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new …

Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival,
but this transformation leaves them reliant on constant supply of nutrients and energy. In …

The alterations in carbohydrate metabolism that fuel tumor growth have been extensively
studied. However, other metabolic pathways involved in malignant progression, demand …

In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as
tools for drug design. By comparing the chemical structures of human metabolites (obtained …

The major obstacle to successful chemotherapy of cancer patients is drug resistance.
Previously we explored the molecular mechanisms of curcumin cross-resistance in …

Abstract Background G-DOC Plus is a data integration and bioinformatics platform that uses
cloud computing and other advanced computational tools to handle a variety of biomedical …

Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have
been shown to play a role in the survival and proliferation of cancer cells. This study aimed …

Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese
medicine. Its potential impact on endometrial cancer has not been thoroughly investigated …

Abstract In traditional Chinese medicine, Salvia miltiorrhiza Bunge (danshen) is widely used
in the treatment of numerous cancers. However, its clinical effort and mechanism in the …

Currently, the development of new effective drugs for cancer therapy is not only hindered by
development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug …