There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

Carvedilol is one of the most effective beta blockers for preventing ventricular
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …

Spontaneous Ca2+ release from intracellular stores is important for various physiological
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

There is much evidence showing that some lethal ventricular arrhythmias arise from waves
of Ca2+ release from the sarcoplasmic reticulum (SR) that propagate along cardiac cells …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …

Abstract According to the American Heart Association it is estimated that the United States
will spend close to $39 billion in 2010 to treat over five million Americans suffering from …

Ryanodine receptors (RyR) are intracellular Ca 2+-permeable channels that provide the
sarcoplasmic reticulum Ca 2+ release required for skeletal and cardiac muscle contractions …